I have a Server 2012 R2 2 node cluster with a ~76 TB File share (X:) and a ~10TB File share (Y:) each of these runs on opposing nodes, they have been in production about 18 months.
Starting about 3 months ago users started complaining about files they opened not being able to be saved as the same file name because the file was locked. and this morning an entire folder went missing. the problem has been increasing from monthly to weekly to now daily.
the X share had file de-duplication turned on which i turned off and the problem has seemed to go away on that share.
the Y share hasn't had de-duplication turned on since testing phase, but it is still having the same issue.