Windows Failover cluster between Physical and Virtual nodes

Dear Team,

One of our customer wants to build a SQL Cluster where 1^st node is Physical server and 2^nd node will be VM running on VMware ESX 6.0.

As per my understanding MS supports this type of configuration in Windows 2012.

During Failover Cluster Validation – it failed at validating “MS MPIO based disks”

We were able to continue to cluster implementing by skipping this test, since we know these 2 nodes are having different version / type of MPIO. ( physical & Virtual )

We would like to know should It be any major issue or we can just continue using this setup, as this is going to be one of the critical database server in production.

Please provide your best supported configuration document from Microsoft.

Thanks,

ABUL